Dr. Gary Ruvkun — RUVKUN LAB

Gary Ruvkun

Major Research Interests

microRNA and RNA interference mechanisms, genetic analysis of animal antiviral and antibacterial pathways, aging, life on other planets.

Academic trajectory

1985 - present Asst, Assoc., Professor of Genetics, Harvard Medical School

1982 ‑ 1985 Junior Fellow, Society of Fellows, Harvard University

1982 Ph.D. Harvard University (Biophysics)

1973 A.B. University of California at Berkeley (Biophysics)

Honors

2004 Rosenstiel Award, Brandeis University (with Victor Ambros, Andy Fire, Craig Mello)

2008 National Academy of Sciences

2008 Benjamin Franklin Medal, Franklin Institute (with Victor Ambros and David Baulcombe)

2008 Albert Lasker Award for Basic Medical Research (with Victor Ambros and David Baulcombe)

2008 Canada Gairdner International Award (with Victor Ambros)

2008 Warren Triennial Prize, Massachusetts General Hospital (with Victor Ambros)

2009 Louisa Gross Horwitz Prize, Columbia University (with Victor Ambros)

2009 American Academy of Arts and Sciences

2009 Shaul and Meira Massry Prize (with Victor Ambros)

2009 National Academy of Medicine

2011 Dan David Prize (with Cynthia Kenyon)

2012 Paul Janssen Award for Biomedical Research (with Victor Ambros)

2013 Ipsen Foundation Longevity Prize

2013 Irving Wright Award, American Foundation for Aging Research

2014 Wolf Prize in Medicine (with Victor Ambros)

2014 Gruber Genetics Prize (with Victor Ambros and David Baulcombe)

2015 Breakthrough Prize in Life Sciences

2016 March of Dimes Prize in Developmental Biology (with Victor Ambros)

2019 American Philosophical Society

2024 Nobel Prize in Physiology or Medicine (with Victor Ambros)

Publications in reverse chronological order:

190. Patange, O, P Breen, G Ruvkun 2024. Perturbed sulfur homeostasis allows C. elegans to escape growth retardation on Actinobacteria from its natural microbiome. 2024. In press, Cell Reports. bioRxiv 2023.11.12.566774; doi: https://doi.org/10.1101/2023.11.12.566774

189. Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G. Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference. In press, PloS Biology. bioRxiv. 2024 Jul 16:2024.07.12.603258. doi: 10.1101/2024.07.12.603258. PMID: 39071373

188. Xu W, Sun Y, Breen P, Ruvkun G, Mao K. Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense. Proc Natl Acad Sci U S A. 2024 121(49):e2416982121. doi: 10.1073/pnas.2416982121. Epub 2024 Nov 27. PMID: 39602251

187. Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N. 2024 Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. PLoS Biol. 2024 22:e3002720. doi: 10.1371/journal.pbio.3002720. PMID: 38991033

186. Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G. 2024 Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024 12:RP89173. doi: 10.7554/eLife.89173. PMID: 37205365

185. Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G. 2024 CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Curr Biol. 2024 34:27282738.e6. doi: 10.1016/j.cub.2024.04.079. Epub 2024 May 28. PMID: 38810637

184. Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK. 2024 Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024 5:S0092-8674(23)01342-9. doi: 10.1016/j.cell.2023.12.010. PMID: 38215760

183. Mao K, Breen P, Ruvkun G. 2022 The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2215966119. doi: 10.1073/pnas.2215966119. 22 Nov 29. PMID: 36445965

182. Ji F, Bonilla G, Krykbaev R, Ruvkun G, Tabach Y, Sadreyev RI. 2022 DEPCOD: a tool to detect and visualize co-evolution of protein domains. Nucleic Acids Res. 2022:gkac349. doi: 10.1093/nar/gkac349. PMID: 35536332

181. Craven E, M Winters, AL Smith, E Lalime, R Mancinelli, B Shirey, W Schubert, A Schuerger, M Burgin, EP Seto, M Hendry, A Mehta, JN Benardini, G Ruvkun 2021. Biological safety in the context of backward planetary protection and Mars sample return: conclusions from the sterilization working group 2021. International Journal of Astrobiology 20: 1-28.

180. Ruvkun, G, F Ji, and RI Sadreyev. 2021. Phylogenetic evidence for asparagine to aspartic acid protein editing of N-glycosylated SARS-CoV-2 viral proteins by NGLY1 deglycosylation/deamidation suggests an unusual vaccination strategy. bioRxiv posting September 12, 2021. doi: https://doi.org/10.1101/2021.09.11.459891

179. Bryan NC, Lebreton F, Gilmore M, Ruvkun G, Zuber MT, Carr CE. Genomic and Functional Characterization of Enterococcus faecalis Isolates Recovered From the International Space Station and Their Potential for Pathogenicity. Front Microbiol. 2021 Jan 11;11:515319. doi: 10.3389/fmicb.2020.515319. PMID: 33505359

178. Warnhoff, K, TW. Hercher, RR Mendel, G Ruvkun. 2021. Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans, Genes Dev. 2021 Jan 14. doi: 10.1101/gad.345579.120. PMID: 33446569 bioRxiv 2020.10.08.332338; doi: https://doi.org/10.1101/2020.10.08.332338

177. Charlesworth. AG*, U Seroussi*, NJ Lehrbach*, MS Renaud, AE Sundby, RI Molnar, RX Lao, AR Willis, JR Woock, MJ Aber, AJ Diao, AW Reinke, GRuvkun, JM Claycomb. 2021. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res 2021 49:8836-8865. doi: 10.1093/nar/gkab619. PMID: 34329465 PMCID: PMC8421154 DOI: 10.1093/nar/gkab619.

176. Mao K, P Breen, G Ruvkun 2020. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020 18(12):e3000996. doi: 10.1371/journal.pbio.3000996. PMID: 33264285

175. Govindan, JA, E Jayamani, V Lelyveld, J Szostak, and G Ruvkun. 2020. Bacterial carotenoids suppress Caenorhabditis elegans surveillance and defense of translational dysfunction. bioRxiv 2020.01.08.898668; doi: https://doi.org/10.1101/2020.01.08.898668

174. Carr, CE, NC Bryant, KN Saboda, SA Bhattaru, G Ruvkun MT Zuber 2020. Nanopore sequencing at Mars, Europa, and microgravity conditions NPJ Microgravity 6:24. doi: 10.1038/s41526-020-00113-9. PMID: 32964110

173. Wei W and Gary Ruvkun 2020. Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism bioRxiv 2020.04.20.049502; doi: https://doi.org/10.1101/2020.04.20.049502. Proc Natl Acad Sci USA. 2020 117(33):19970-19981. doi: 10.1073/pnas.2008021117. PMID: 32737159

172. Fischer, SEJ and G Ruvkun. 2020. Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci USA 117:5987-5996. doi: 10.1073/pnas.1919028117. 20 Mar 2. PMID: 32123111

171. Govindan, JA, E Jayamani, and G Ruvkun. 2019. ROS-based lethality of C. elegans mitochondrial electron transport mutants grown on E. coli siderophore iron release mutants Proc Natl Acad Sci USA. 116:21651-21658. doi: 10.1073/pnas.1912628116. PMID: 31591219

170. Armakola M and G Ruvkun 2019. Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci USA. pii: 201820928. doi: 10.1073/pnas.1820928116. PMID:31164416

169. Mojarro A, J Hachey, R Bailey, M Brown, R Doebler, G Ruvkun, MT Zuber, and CE Carr. 2019. Nucleic acid extraction and sequencing from low-biomass synthetic Mars analog soils for in situ life detection. Astrobiology. doi: 10.1089/ast.2018.1929. PMID:31204862

168. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. 2019. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell 177:1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. PMID: 31031004

167. Lehrbach NJ, PC Breen, and G Ruvkun. 2019. Protein sequence editing of SKN-1A/Nrf1 by peptide:N-glycanase controls proteasome gene expression. Cell 177:737-750.e15. doi: 10.1016/j.cell.2019.03.035. PMID: 31002798

166. Lehrbach NJ and G Ruvkun. 2019. ER-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 11;8. pii: e44425. doi: 10.7554/eLife.44425. PMID: 30973820

165. Warnhoff K and G Ruvkun. 2019. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 15(5):480-488. doi: 10.1038/s41589-019-0249-y. 19 Mar 25. PMID: 30911177

164. Mao K, F Ji, PC Breen, A Sewell, M Han, R Sadreyev, and G Ruvkun. 2019. Mitochondrial dysfunction in C. elegans activates mitochondrial relocalization and nuclear hormone receptor-dependent detoxification genes. Cell Metab. 29(5):1182-1191.e4. doi: 10.1016/j.cmet.2019.01.022. PMID: 30799287

163. Kniazeva M and G Ruvkun. 2019. Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proceedings of the National Academy of Sciences, Proc Natl Acad Sci USA. 116(9):3784-3792. doi: 10.1073/pnas.1815656116. PMID: 30808764

162. Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR 3rd, Ruvkun G, Riedel CG. 2018. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 9(1):4400. doi: 10.1038/s41467-018-06624-0. PMID: 30353013

161. Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. 2018. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection. PMID:30287474

160. Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE 2018. Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 18:80-86. doi: 10.1016/j.lssr.2018.05.004. PMID: 30100151

159. Carr CE, NC Bryan, KN Saboda, SA Bhattaru, G Ruvkun, MT Zuber. 2018. Acceleration profiles and processing methods for parabolic flight NPJ Microgravity. 4:14. doi: 10.1038/s41526-018-0050-3. eCollection 2018. PMID: 30109261

158. Alexander JK, JR Casani, L Chiao, DP Fidler, J Gabrynowicz, GS Hubbard, EH Levy, N Noonan, K Olden, F Raulin, G Ruvkun, MP Saunders, BA Simmons, PD Stabekis, A Steele, DH Smith. 2018. Review and Assessment of Planetary Protection Policy Development Processes. Committee on the Review of Planetary Protection Policy Development Processes, Space Studies Board. https://doi.org/10.17226/25172.

157. Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, G Ruvkun. 2018. The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018 May 1;32(9-10):670-681. doi: 10.1101/gad.311514.118. PMID: 29739806

156. Mojarro A, J Hachey, G Ruvkun, MT Zuber, & CE Carr. 2018. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 19:108. doi: 10.1186/s12859-018-2124-3. PMID:29587645

155. Pontefract A, TF Zhu, VK Walker, H Hepburn, C Lui, MT Zuber, G Ruvkun, and CE Carr. 2017. Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Frontiers in Microbiology, section Extreme Microbiology, Front Microbiol. 2017 Sep 26;8:1819. doi: 10.3389/fmicb.2017.01819. PMID:29018418

154. Mojarro A, Ruvkun G, Zuber MT, Carr CE. 2017 Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017 Jul 13. doi: 10.1089/ast.2016.1535. PMID:28704064

153. Lehrbach NJ and G Ruvkun. 2016. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016 Aug 16;5. pii: e17721. doi: 10.7554/eLife.17721. PMID:27528192

152. Dowen RH, PC Breen, T Tullius, AL Conery, and G Ruvkun. 2016. A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016 Jul 1;30(13):1515-28. doi: 10.1101/gad.283895.116. PMID:27401555

151. Samuel BS, H Rowedder, C Braendle, MA Félix, G Ruvkun 2016. Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci USA., 2016.. pii: 201607183. PMID:27317746

150. Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F 2016. Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. 16(2):119-25. doi: 10.1089/ast.2016.1472. PMID: 26848950.

149. Govindan JA, Jayamani E, Zhang X, Mylonakis E, and G Ruvkun 2015. Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci USA. pii: 201517448. PMID: 26392561

148. Govindan JA, E Jayamani, X Zhang, P Breen, J Larkins-Ford, E Mylonakis and G Ruvkun. 2015. Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015 Oct;17(10):1294-303. doi: 10.1038/ncb3229. PMID: 26322678. Author Correction: Nat Cell Biol. 2022 doi: 10.1038/s41556-022-00868-1. PMID: 35411089

147. Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA. 2015. piRNAs and piRNA-dependent siRNAs protect conserved and essential C. elegans genes from misrouting into the RNAi pathway. Dev Cell. 2015 Aug 24;34(4):457-65. doi: 10.1016/j.devcel.2015.07.009. Aug 13.PMID:26279487

146. Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. 2015. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. Jul 1;43(W1):W154-9. doi: 10.1093/nar/gkv452. May 9. PMID: 25958392

145. Kirienko NV, FM Ausubel, and G Ruvkun 2015. Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci USA., 2015 Feb 10;112(6):1821-6. doi: 10.1073/pnas.1424954112. Jan 26. PMID:25624506

144. Wang MC, HD Oakley, CE Carr, JN Sowa, G Ruvkun 2014. Gene pathways that delay Caenorhabditis elegans reproductive senescence. PLoS Genet. 2014 Dec 4;10(12):e1004752. doi: 10.1371/journal.pgen.1004752. eCollection 2014 Dec. PMID: 25474471

143. Garcia SMDA, Y Tabach, G Lourenço, and G Ruvkun 2014. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nature Structural and Molecular Biology, 2014 Aug;21(8):712-20. doi: 10.1038/nsmb.2858. Jul 20.PMID: 25038802.

142. Phillips CM, Rim Y, Roovers, E, Breen PC, Ohsumi, TK, van Wolfswinkel, JC, Ketting, RF, Ruvkun, G, TA Montgomery 2014. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Current Biology 2014 Apr 14;24(8):839-44. doi: 10.1016/j.cub.2014.02.060. Mar 27. PMCID: PMC4010136

141. Liu Y, BS Samuel, PC Breen and G Ruvkun 2014. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014 Apr 17;508(7496):406-10. doi: 10.1038/nature13204. Apr 2. PMCID: PMC4102179

140. Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. 2013. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 2013 Dec 5;155(6):1409-21. doi: 10.1016/j.cell.2013.10.047. Nov 21. PMCID: PMC3956118

139. Fischer SEJ, Q Pan, PC. Breen, Y Qi, Z Shi, C Zhang, TA Montgomery, and G Ruvkun 2013. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes and Development, 2013 Dec 15;27(24):2678-95. doi: 10.1101/gad.233254.113, PMCID: PMC3877757

138. Soukas AA, CE Carr, and G Ruvkun 2013. Genetic Regulation of C. elegans Lysosome Related Organelle Function. PloS Genetics, Oct;9(10):e1003908. doi: 10.1371/journal.pgen.1003908. Oct 24. PMCID: PMC3812091

137. Tabach Y, T Golan, A Hernández-Hernández AR Messer, T Fukuda, A Kouznetsova, JG Liu, I Lilienthal, C Levy, and G Ruvkun 2013. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Molecular Systems Biology, Oct 1;9:692. doi: 10.1038/msb.2013.50. PMCID: PMC3817400

136. Shi Z, G Hayes, and G Ruvkun 2013. Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PloS One, Sep 13;8(9):e75475. doi: 10.1371/journal.pone.0075475. PMCID: PMC3772890

135. Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, and G Ruvkun 2013. Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013 Jun 4. PMID: 23734755

134. O’Rourke EA and G Ruvkun 2013. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nature Cell Biology, 2013 Jun;15(6):668-76. doi: 10.1038/ncb2741. Apr 21. PMCID: PMC3723461

133. Kirienko NV, DR Kirienko, J Larkins-Ford, C Wählby, G Ruvkun, FM Ausubel 2013 Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host and Microbe, 13(4):406-16. doi: 10.1016/j.chom.2013.03.003. PMCID: PMC3641844

132. Riedel CG, G Lima, NV. Kirienko, T Heimbucher, JA West, A Dillin, J Asara, and G Ruvkun 2013. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nature Cell Biology, 2013 May;15(5):491-501. doi: 10.1038/ncb2720. Apr 21. PMCID: PMC3748955

131. O’Rourke EA, P Kuballa, R Xavier, and G Ruvkun 2013. w-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes and Development Feb 15;27(4):429-40. doi: 10.1101/gad.205294.112. Feb 7. PMCID: PMC3589559

130. Shi Z, T Montgomery, Y Qi and G Ruvkun 2013. High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA and siRNA pathways in nematodes. Genome Research Mar;23(3):497-508. doi: 10.1101/gr.149112.112. Jan 30. PMCID: PMC3589538

129. Tabach Y, A Billi, G Hayes, O Zuk, H Gabel, R Kamath, M Newman, K Yacoby, B Chapman, M Borowsky, J Kim, and G Ruvkun 2013. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature Jan 31;493(7434):694-8. doi: 10.1038/nature11779. Dec 23. PMCID: PMC3762460

128. Carr CE, H Rowedder, C Vafadari, CS Lui, E Cascio, MT Zuber, and G Ruvkun 2013. Radiation resistance of biological reagents for in-situ life detection. Astrobiology Jan;13(1):68-78. doi: 10.1089/ast.2012.0869. PMID: 23330963

127. Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks 2012. PLoS One 2012;7(10):e48282. doi: 10.1371/journal.pone.0048282. Oct 29. PMCID: PMC3483217

126. Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE 2012. An image analysis toolbox for high-throughput C. elegans assays Nat Methods 9:714-6. doi: 10.1038/nmeth.1984. PMCID: PMC3433711

125. Shore DE, CE Carr and G Ruvkun 2012. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PloS Genetics 8(7):e1002792. PMCID: PMC3400582

124. Phillips CM, PC Breen, TA Montgomery and G Ruvkun 2012. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes and Development 26:1433-44. Jun 19. PMCID: PMC3403012

123. Zhang C, TA Montgomery, SE Fischer, SM Garcia, CG Riedel, N Fahlgren, CM Sullivan, JC Carrington and G Ruvkun 2012. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Current Biology 22:881-90. Apr 26. PMCID: PMC3371361

121. Melo JA and G Ruvkun 2012. Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell 149:452-66. PMCID: PMC3613046

120. Montgomery TA, Rim, E, Zhang, C, Dowen RH, Phillips CM, Fischer, SEJ and G. Ruvkun 2012. PIWI associated siRNAs and piRNAs specifically require the C. elegans HEN1 ortholog henn-1. PLoS Genetics, Apr;8(4):e1002616. Apr 19. PMCID: PMC3334881

119. Shi Z and G. Ruvkun 2012. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci USA. Mar 20;109(12):4568-73. Mar 6. PMCID: PMC3311396

118. Wu X, Z Shi, M Cui, M Han and G. Ruvkun 2012. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. Mar;8(3):e1002542. Mar 8. PMCID: PMC3297578

117. Kimura KD, Riddle DL, and G. Ruvkun 2011 The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status. Cold Spring Harb Symp Quant Biol. 76:113-20. Nov 28. PMID: 22123849

116. Russel S, AR Frand, and G Ruvkun 2011. Regulation of the C. elegans molt by pqn-47. Developmental Biology 360: 297-309. PMCID: PMC3618673

115. Fischer SEJ, TA Montgomery, C Zhang, N Fahlgren, A Hwang, CM Sullivan, JC Carrington and G Ruvkun 2011. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. Nov;7(11):e1002369. Nov 10. PMCID: PMC3213143

114. Hayes GD, C Riedel, and G Ruvkun 2011. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. Oct 1;25(19):2079-92. PMCID: PMC3197206

113. Wang MC, W Min, G Ruvkun, XS Xie 2011. RNAi screening for fat regulatory genes with SRS microscopy. Nature Methods, Feb;8(2):135-8. Jan 16. PMCID: PMC3061290

112. Zhang C, TA Montgomery, HW Gabel, SE Fischer, CM Phillips, N Fahlgren, C Sullivan, JC Carrington, and G Ruvkun 2011. mut-16 and other mutator-class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc. Natl. Acad. Sci., Jan 25;108(4):1201-8. Jan 18. PMCID: PMC3029761

111. Meli VS, Osuna B, Ruvkun G, Frand AR 2010. MLT-10 Defines a Family of DUF644 and Proline-rich Repeat Proteins Involved in the Molting Cycle of Caenorhabditis elegans. Mol Biol Cell. May 15;21(10):1648-61. PMCID: PMC2869372

110. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT 2009. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009 Dec 14;4(12):e8210. PMCID: PMC2788130

109. O'Rourke EJ, Soukas AA, Carr CE, G Ruvkun 2009. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab.10(5):430-5. PMCID: PMC2921818

108. Curran SP, X Wu, C Riedel, and G Ruvkun 2009. A soma-to-germline transformation in long-lived C. elegans mutants. Nature 459: 1079-84. PMCID: PMC2716045

107. Butcher RA, JR Ragains, G Ruvkun, J Clardy, HY Mak. 2009 Biosynthesis of the C. elegans dauer pheromone. Proceedings of the National Academy of Sciences 106(6):1875-9. PMCID: PMC2631283

106. Soukas AA, EA Kane, CE Carr, JA Melo, and G Ruvkun 2009. Rictor/TORC2 regulates fat metabolism, feeding, growth, and lifespan in Caenorhabditis elegans. Genes and Development 23: 496-511. PMCID: PMC2648650

105. Isenbarger TA, CE Carr, SS Johnson, M Finney, GM Church, W Gilbert, MT Zuber, and G Ruvkun 2008. The most conserved genome segments for life detection on Earth and other planets, Origin of Life and Evolution of Biospheres, 38(6):517-33. Oct 14. PMID: 18853276

104. Wang MC, E O’Rourke and G Ruvkun 2008. Fat metabolism links germline stem cells and longevity in C. elegans. Science 322: 957-60. PMCID: PMC2760269

103. Fischer SEJ, MD Butler, Q Pan and G Ruvkun 2008. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature 455: 491-6. PMCID: PMC2756026

102. Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun G, Kaplan JM, Kim JK 2008. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell 133: 903-15. PMCID: PMC2553566

101. Patel DS, Fang LL, Svy DK, Ruvkun G, Li W 2008. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 135: 2239-49. PMID: 18495818

100. Gabel HW and G. Ruvkun 2008. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 15: 531-3. PMCID: PMC2910399

99. Samuelson AV, RR Klimczak, D Thompson, CE Carr, and G Ruvkun 2008. Identification of C. elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2007;72:489-97. PMID: 18419309

98. Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA 2008. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 10(1):106-13. PMCID: PMC2637451

97. Isenbarger TA, M Finney, C Ríos-Velázquez, J Handelsman, and G Ruvkun 2007. Miniprimer PCR, a new lens for viewing the microbial world. Appl Environ Microbiol. 2008 Feb;74(3):840-9. PMCID: PMC2227730

96. Parry DH, Xu, J and G Ruvkun 2007 A whole-genome RNAi screen for C. elegans miRNA pathway genes. Current Biology 17: 2013-22. PMCID: PMC2211719

95. Samuelson AV, Carr, CE, and G Ruvkun 2007. Gene activities that mediate increased lifespan of C. elegans insulin-like signaling mutants. Genes and Development 21:2976-94. PMCID: PMC2049198

94. Kim N, Dempsey C, Kuan CJ, Zoval J, O'Rourke E, Ruvkun G, Madou M, J Sze 2007. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in C. elegans. Genetics. 177:835-45. PMCID: PMC2034647

93. Curran SP and G Ruvkun 2007. Lifespan regulation by evolutionarily conserved genes essential for viability. PloS Genetics 3(4):e56. PMCID: PMC1847696

92. Hayes GD and G Ruvkun 2006. Misexpression of the C. elegans miRNA let‑7 is sufficient to drive developmental programs. Cold Spring Harbor Symp Quant Biol. 71: 21-7. Regulatory RNAs. PMID: 17381276

91. Ruvinsky I, U Ohler, CB Burge, and G Ruvkun 2006. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 302: 617-26. PMID: 17046742

90. Hayes GD, AR Frand, and G. Ruvkun 2006. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 133: 4631-4641. PMID: 17065234

89. Hu PJ, J Xu, and G Ruvkun 2006. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul;2(7):e99. PMCID: PMC1487177

88. Sandoval GM, JS Duerr, J Hodgkin, JB Rand and G Ruvkun 2006. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nature Neuroscience, 9:599-601. PMID: 16604067

87. Mak HY, LS Nelson, M Basson, CD Johnson and G Ruvkun 2006. Polygenic control of C. elegans fat storage. Nature Genetics 38:363-8. PMID: 16462744

86. Duchaine TF, JA Wohlschlegel, S Kennedy, Y Bei, D Conte, K Pang, DR Brownell, S Harding, S Mitani, G Ruvkun, JR Yates, and CC Mello 2006. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 124:343-54. PMID: 16439208

85. Frand AR, S Russel, G Ruvkun 2005. Functional genomic analysis of C. elegans molting. PLoS Biol. 2005 Oct;3(10):e312. doi: 10.1371/journal.pbio.0030312. PMID: 16122351

84. Wang DS, S Kennedy, D Conte, J Kim, H Gabel, R Kamath, C Mello, and G Ruvkun 2005. Somatic misexpression of germline P granules and enhanced RNA interference in Retinoblastoma pathway mutants. Nature 436: 593-597. PMID: 16049496

83. Sieburth D, Q Ch ng, M Dybbs, M Tavazoie, S Kennedy, D Wang, D Dupuy, J Rual, D Hill, M Vidal, G Ruvkun, and J Kaplan 2005. Systematic analysis of genes required for synapse structure and function. Nature 436: 510-517. PMID: 16049479

82. Hamilton B, Y Dong, M Shindo, W Liu, G Ruvkun, and SS Lee 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes and Development 19:1544-55. PMCID: PMC1172061

81. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P 2005. Analysis of xbx genes in C. elegans. Development. 132:1923-34. PMID: 15790967

80. Kim JK, HW Gabel, RS Kamath, M Tewari, A Pasquinelli, S Kennedy, M Dybbs, N Bertin, M Vidal, JM Kaplan, and G Ruvkun 2005. Functional genomic analysis of RNA interference in C. elegans. Science 308: 1164-7. PMID: 15790806

79. Wang D and G Ruvkun 2004. The insulin pathway regulates RNAi in C. elegans. Cold Spring Harbor Symposium on Quantitative Biology, 69th edition, 69: 429-433.

78. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT 2004. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 36:1079-83. PMID: 15361871

77. Mak HY and G Ruvkun 2004. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development, 131:1777-86. PMID: 15084462

76. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M 2004. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Molecular Cell 13:469-82. PMID: 14992718

75. Kennedy SK, D Wang, and G Ruvkun 2004. A conserved siRNA degrading RNase negatively regulates RNA interference in C. elegans. Nature 427: 645-9. PMID: 14961122

74. Kim J, Krichevsky, A, Grad, Y, Hayes, GD, Kosik, KS, Church, GM, and G Ruvkun 2004. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci.101: 360-5. PMCID: PMC314190

73. Sze JY and G Ruvkun 2003. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity, Proc. Natl. Acad. Sci., 100:9560-5. PMCID: PMC170957

72. Ruvinsky I and G Ruvkun 2003. Functional tests of enhancer conservation between distantly related species, Development, 130:5133-42. PMID: 12944426

71. Garsin DA. JM Villanueva, J Begun, DH Kim, CD Sifri, SB Calderwood, G Ruvkun, and FM Ausubel 2003. Long-Lived Caenorhabditis elegans daf-2 mutants are resistant to bacterial pathogens, Science, 300:1921. PMID: 12817143

70. Grad Y, Aach, J, Hayes, GD, Reinhart, B, Church, GM, Ruvkun, G, and J Kim. 2003. Computational and experimental identification of C. elegans microRNAs. Molecular Cell, 11:1253-63. PMID: 12769849

69. Lee SS, Kennedy,S, Tolonen, AC and G Ruvkun 2003. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 300:644-7. PMID: 12690206

68. Aspöck G, G Ruvkun, and T Bürglin 2003. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development, 130:3369-3378. PMID: 12810585

67. Pasquinelli AE, McCoy, A Jimenez, E Salo, G Ruvkun, M Martindale, and J Baguñà 2003. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: A role in life history evolution? Evolution and Development, 5:372-378. PMID: 12823453

66. Bashirullah A, Pasquinelli, AE Kiger, A, Perrimon, N, Ruvkun, G, and C S Thummel 2003. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Developmental Biology, 259:1-8. PMID: 12812783

65. Li W and G Ruvkun 2003. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes and Development, 17: 844-58. PMCID: PMC196030

64. Ashrafi K, Chang, FY,Watts, JL, Fraser, AG, Kamath, RS, Ahringer, J and G Ruvkun 2003. Genome-wide RNAi analysis of C. elegans fat regulatory genes. Nature, 421:268-72. PMID: 12529643

63. Lee SS, Lee, RY, Fraser, AG, Kamath, RS, Ahringer, J and G Ruvkun 2002. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics, 33:40-8. PMID: 12447374

62. Wolkow CA, Munoz MJ, Riddle DL, G Ruvkun 2002. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 277:49591-7. PMID: 12393910

61. Ruvkun G, M Finney, W Gilbert, G Church. 2002. A Robotic-PCR Detector for DNA-based Life on Other Planets, in Signs of Life: A Report based on the April 2000 Workshop on Life Detection Techniques. Space Sciences Board, NASA.

60. Sze JY, Zhang, S, Li, J, and G Ruvkun 2002. The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development, 129:3901-11. PMID: 12135927

59. Lee RYN, Hench, J, and G Ruvkun 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 11: 1950-1957. PMID: 11747821

58. Grishok A, Pasquinelli, AE, Conte, D, Li, N, Parrish, S, Ha, I, Baillie, DL, Fire, A, Ruvkun, G, and Mello, CC 2001. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control Caenorhabditis elegans developmental timing. Cell 106: 23-34. PMID: 11461699

57. Pierce SB, Costa, M, Wisotzkey, R, Devadhar, S, Homburger, SA, Buchman, AR, Ferguson, KC, Heller, J, Platt, DM, Liu, LX, Pasquinelli, AE, Doberstein, SK, G Ruvkun 2001. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes and Development 15: 672-686. PMCID: PMC312654

56. Bürglin TR and G Ruvkun 2001. Regulation of ectodermal and excretory cell function by the C. elegans POU homeobox gene ceh-6 Development 128: 779-790. PMID: 11171402

55. Reinhart BJ and G Ruvkun 2001. Isoform-specific mutations in the Caenorhabitis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 157: 199-209. PMCID: PMC1461488

54. Cahill CM, Tzivion, G, Nasrin, N, Ogg, S, Dore, J, Ruvkun, G, and M Alexander-Bridges 2001. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 276: 13402-10. PMID: 11124266

53. Wolkow CA, Kimura, KD, Lee, M and G Ruvkun 2000. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290:147-50. PMID: 11021802

52. Pasquinelli A, Reinhart, B, Slack F, Maller, B, Kuroda, M, Martindale, M, Srinivasan, A, Fishman, M, Hayward D, Ball E, Degnan, B, Müller, P, Spring, J, Finnerty, J, Corbo, J, Levine, M, Leahy, P, Davidson, E, and G Ruvkun 2000. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408: 86-89. PMID: 11081512

51. Nasrin N, Ogg, S, Cahill, C, Biggs, W, Nui, S, Dore, J, Calvo, D, Shi, Y, Ruvkun, G, and M Alexander-Bridges 2000. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl. Acad. Sci., 97: 10412-7. PMCID: PMC27038

50. Kagoshima H, Sommer, R, Reinhart, B, Ruvkun, G, Cassata, G, and TR Bürglin 2000. Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Development Genes and Evolution 210:564-569. PMID: 11180807

49. Slack FJ, Basson, M, Liu, Z, Ambros, V, Horvitz, HR, and G Ruvkun 2000. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the lin-29 transcription factor. Mol. Cell 5: 659-69. PMID: 10882102

48. Reinhart BJ, Slack, FA., Basson, M, Pasquinelli, AE, Bettinger, JC, Rougvie, AC, Horvitz, HR, and G Ruvkun 2000. The 21 nucleotide let-7 RNA regulates developmental timing in C. elegans. Nature, 403: 901 - 906. PMID: 10706289

47. Sze JY, Victor, M, Loer, C, Shi, Y, and G Ruvkun 2000. Food and metabolic signaling defects in a C. elegans serotonin-synthesis mutant, Nature 403: 560-4. PMID: 10676966

46. Tissenbaum HA Hawdon, J, Perregaux, M, Hotez, P, Guarente, L, and G Ruvkun 2000. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc. Natl. Acad. Sci. 97: 460-465. PMCID: PMC26685

45. Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI 1999. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev 13: 1794-80. PMCID: PMC316880

44. Paradis S, Ailion, M, Toker A, Thomas, JH, and G Ruvkun 1999. A PDK1 homolog is necessary and sufficient to Transduce AGE-1 PI3 kinase signals that regulate diapause in C. elegans. Genes and Development 13: 1438-1452. PMCID: PMC316759

43. Hobert O, Tessmar K and G Ruvkun 1999. The C. elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126, 1547-1562. PMID: 10068647

42. Hobert O, Moerman DG, Clark KA, Beckerle MC, and G Ruvkun 1999. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol 144: 45-57. PMCID: PMC2148118

41. Slack F and G Ruvkun 1998. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci 23:474-5. PMID: 9868369

40. Hobert O and G Ruvkun 1998. A common theme for LIM homeobox gene function across phylogeny? Biol. Bull. 195: 377-80. PMID: 9924780

39. Ogg S and G Ruvkun 1998. The C. elegans PTEN homolog DAF-18 acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-93. PMID: 9885576

38. Ruvkun G and O Hobert 1998. The taxonomy of developmental control in Caenorhabditis elegans. Science 282: 2033-41. PMID: 9851920

37. Paradis S and G Ruvkun 1998. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes and Development 12: 2488-98. PMCID: PMC317081

36. Hobert O, Liu, Y, D’Alberti, T, and G Ruvkun 1998. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J. Neuroscience 18: 2084-2096. PMID: 9482795

35. Tissenbaum HA and G Ruvkun 1998. An insulin-like signaling pathway affects both longevity and reproduction in C. elegans. Genetics 148: 703-717. PMCID: PMC1459840

34. Ogg S, Paradis, S, Gottlieb, S, Patterson, GI, Lee, L, Tissenbaum, HA, and G Ruvkun 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999. PMID: 9353126

33. Kimura KD, Tissenbaum, HA, Liu, Y and G Ruvkun 1997. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science 277: 942-946. PMID: 9252323

32. Patterson G I, Koweek, A, Wong, A, Liu, Y, and G Ruvkun 1997. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the C. elegans dauer pathway. Genes and Development 11: 2679-2690. PMCID: PMC316611

31. Hobert O, Mori, I, Yamashita, Y, Honda, H, Ohshima, Y, Liu, Y and G Ruvkun 1997. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19: 345-357. PMID: 9292724

30. Sluder AE, Lindblom, T and G. Ruvkun 1997. The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Developmental Biology 184: 303-319. PMID: 9133437

29. Sze JY, Liu, Y and G Ruvkun 1997. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development 124: 1159-1168. PMID: 9102303

28. Ha I, Wightman, B and G Ruvkun 1996. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes and Development 10: 3041-3050. PMID: 8957004

27. Barnes TM, Jin, Y, Horvitz, HR, Ruvkun, G, and S Hekimi 1996. The C. elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and non-specific lipid transfer protein. J. of Neurochemistry 67: 46-57. PMID: 8667025

26. Morris JZ, Tissenbaum, HA and G Ruvkun 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-538. PMID: 8700226

25. Baumeister R, Liu, Y, and G Ruvkun 1996. Lineage specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes and Development 10: 1395-1410. PMID: 8647436

24. Greenstein D, Hird, S Plasterk, R, Andachi, Y, Kohara, Y, Wang, B, Finney, M, and G Ruvkun 1994. Targeted mutations in the C. elegans POU-homeobox gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes and Development 8: 1935-1948. PMID: 7958868

23. Gottlieb S and G Ruvkun 1994. daf-2, daf-16, daf-23: genetically interacting genes controlling dauer formation in C. elegans. Genetics 137: 107-120. PMCID: PMC1205929

22. Wightman B, I Ha, and G Ruvkun 1993. Post-transcriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862. PMID: 8252622

21. Bürglin TR and G Ruvkun 1992. New motif in PBX genes. Nature Genet 1: 319‑320. PMID: 1363814

20. Xue DM, Finney, M, Ruvkun, G and M Chalfie 1992. Regulation of the mec-3 gene by the C. elegans homeoproteins Unc-86 and Mec-3. EMBO J. 11: 4969‑4979. PMCID: PMC556975

19. Miller D, Shen, M, Shamu, C, Bürglin, T, Ruvkun, G, Ghee, M Dubois, L Wilson 1992 The C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature 355: 841‑845. PMID: 1347150

18. Bürglin TR, Ruvkun, G, Coulson, A, Hawkins, N, McGhee, J, Schaller, D, Wittmann, C, Müller, F, and Waterston, R 1991. Nematode homeobox cluster. Nature 351: 703. PMID: 1676487

17. Ruvkun G, Wightman, B, Bürglin, TR, and P Arasu. 1991. Dominant gain of function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern‑formation genes. Development (Supplement): 47‑54. PMID: 1742500

16. Arasu P, Wightman, B, G Ruvkun 1991. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes and Development 5: 1825‑1833. PMID: 1916265

15. Wightman B, Bürglin, TR, Gatto, J, Arasu, P, G Ruvkun 1991. Negative regulatory sequences in the lin-14 3' untranslated region are necessary to generate a temporal switch during C. elegans development. Genes and Development 5: 1813‑1824. PMID: 1916264

14. Finney M and Ruvkun, G 1990. The unc-86 gene product couples cell lineage and cell identity in Caenorhabditis elegans. Cell 63: 895‑905. PMID: 2257628

13. Ruvkun G, Gilbert, W, Horvitz, HR 1990. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Research 18: 809‑815. PMCID: PMC330331

12. Bürglin TR, Finney, M, Coulson, A, and Ruvkun, G 1989. C. elegans has scores of homeobox-containing genes. Nature 341: 239‑243. PMID: 2571091

11. Ruvkun G and Giusto, J 1989 The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal switch during development. Nature 338: 313‑319. PMID: 2922060

10. Ruvkun G, Ambros, V, Coulson, A, Waterston, R, Sulston, J, and Horvitz, HR 1989. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 121: 501‑516. PMCID: PMC1203636

9. Herr W, Sturm, RA, Clerc, RG, Corcoran, LM, Baltimore, D, Sharp, PA, Ingraham, HA, Rosenfeld, MG, Finney, M, Ruvkun, G, and Horvitz, HR 1988 The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes and Development 2: 1513‑1516. PMID: 3215510

8. Finney M, Ruvkun, G, and Horvitz, HR 1988. The Caenorhabditis elegans cell lineage and differentiation gene unc-86 encodes a protein containing a homeodomain and extended similarity to mammalian transcription factors. Cell 55: 757‑769. PMID: 2903797

7. Ruvkun G, Long SR, Meade HM, van den Bos RC, Ausubel FM 1982. ISRml: a Rhizobium meliloti insertion sequence which preferentially transposes into nitrogen fixation (nif) genes. J Mol Appl Genet 1: 405‑418. PMID: 6296251

6. Ruvkun G, Sundaresan V, Ausubel FM 1982. Directed transposon Tn5 mutagenesis and complementation analysis of the Rhizobium meliloti symbiotic nitrogen fixation (nif) genes. Cell 29: 551‑559. PMID: 6288262

5. Ruvkun G, Sundaresan V, Ausubel FM 1982. Specific protection of nucleotides in the lac operator from dimethyl sulfate (DMS) methylation of DNase I nicking by crude bacterial extracts. Gene 18: 245‑255. PMID: 6290328

4. Meade HM, Long SR, Ruvkun G, Brown SE, Ausubel FM 1982. Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol 149: 114‑122. PMCID: PMC216598

3. Ruvkun G, Long, SR, Meade, HM, Ausubel, FM 1981. Molecular genetics of symbiotic nitrogen fixation. Cold Spring Harbor Symposium on Quantitative Biology 45: 492‑500.

2. Ruvkun G, Ausubel FM 1981. A general method for site‑directed mutagenesis in prokaryotes. Nature 289: 85‑88.

1. Ruvkun G, Ausubel FM 1980 Interspecies homology of nitrogenase genes. Proc. Natl. Acad. Sci. USA 77: 191‑195. PMCID: PMC348234

2024 In review and/or posted on bioRxiv.

Kniazeva, M and G Ruvkun. 2025. Activation of toxin defense of the ribosome by frameshift fusion of overlapping reading frames. In review at PNAS Dec 2024.

Reviews

17. Ruvkun G, Lehrbach N. Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harb Perspect Biol. 2022 Aug 8:a041266. doi: 10.1101/cshperspect.a041266. PMID: 35940907

16. Ambros V and G Ruvkun 2018. Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018 Jul;209(3):651-673. doi: 10.1534/genetics.118.300291. PMID:29967059

15. Shore DE and G Ruvkun 2013. A Cytoprotective Perspective on Longevity Regulation. Trends in Cell Biology, 23:409-20. doi: 10.1016/j.tcb.2013.04.007. PMCID: PMC4057428

14. Zhang C and G Ruvkun 2012. New insights into siRNA amplification and RNAi. RNA Biology, 9. PMCID: PMC3551858

13. Ruvkun G 2009. Signaling pathways that regulate C. elegans lifespan, Ipsen Foundation Series. Paris.

12. Ruvkun G 2008. The perfect storm of tiny RNAs. Nat Med. 14:1041-5. PMID: 18841145

11. Ruvkun G 2008. Tiny RNA: Where do we come from? What are we? Where are we going? Trends Plant Sci. 13:313-6. PMID: 18562240

10. Ruvkun G 2004. The Tiny RNA World. Harvey Lecture 99: 1-21. PMID: 15984549

9. Ruvkun G, B Wightman, and I Ha 2004. The 20 years it took to recognize the importance of tiny RNAs. Cell S116: S93–S96. PMID: 15055593

8. Pasquinelli AE and G Ruvkun 2002. Control of developmental timing by microRNAs and their targets. Ann. Rev. Cell Biology., 18:495-513. PMID: 12142272

7. Finch CE and G Ruvkun 2001. The Genetics of Aging. Ann. Rev. Genomics and Human Genetics 2: 435-462. PMID: 11701657

6. Davidson, EH and G Ruvkun 1999 Themes from a NASA workshop on gene regulatory processes in development and evolution Journal of Experimental Zoology 285 (2), 104-115

5. Hobert O and G Ruvkun 1999. Pax genes in C. elegans: a new twist. Trends Genet 15: 214-216. PMID: 10354580

4. Slack F and G Ruvkun 1998 Heterochronic genes in development and evolution. Biol. Bull. 195:375-6. PMID: 9924779

3. Ruvkun G 1997. Patterning the Nervous System. In The Nematode Caenorhabditis elegans, Cold Spring Harbor Press, Cold Spring Harbor, NY, p. 543-581. PMID: 21413240

2. Ruvkun G. Generation of temporal and cell lineage asymmetry during C. elegans development. In Molecular Genetics of Development, Springer Verlag, Berlin. 1992.

1. Ruvkun G and M Finney 1991. Regulation of transcription and cell identity by POU domain proteins. Cell 64: 475‑478. PMID: 1991317

Short papers and meeting papers

30. Snoozy J, PC Breen, G Ruvkun, K Warnhoff. 2022. moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans MicroPubl Biol. 2022 Feb 22;2022:10.17912/micropub.biology.000531. eCollection 2022. PMID: 35224462 PMCID: PMC8864482 DOI: 10.17912/micropub.biology.000531.

29. Carr, CE, D Duzdevich, JW Szostak, S Lee, M Taniguchi, T Ohshiro, Y Komoto, G Ruvkun, JM Soderblom, MT Zuber 2020 Electronic Life-detection Instrument for Enceladus/Europa (ELIE) 2020 AGU Fall Meeting Abstracts P044-0002

28. Pontefract, A J Hachey, A Mojarro, VK Walker, H Rowedder, TF Zhu, C Lui, MT Zuber, G Ruvkun, CE Carr 2017 Understanding Habitability and Biosignature Preservation in a Hypersaline Mars Analog Environment: Lessons from Spotted Lake 2017 Lunar and Planetary Science Conference 1964 1124

27. Tani, J, G Ruvkun, MT Zuber, CE Carr 2017 On Neuromorphic Architectures for Efficient, Robust, and Adaptable Autonomy in Life Detection and Other Deep Space Missions Planetary Science Vision 2050 Workshop 1989, 8080

26. Carr, CE, A Mojarro, J Hachey, K Saboda, J Tani, SA Bhattaru, A Smith, A Pontefract, MT Zuber, R Doebler, M Brown, K Herrington, R Talbot, V Nguyen, R Bailey, T Ferguson, M Finney, G Church, G Ruvkun Towards in situ sequencing for life detection 2017 IEEE Aerospace Conference 1-18

25. Carr, CE, G Ruvkun, MT Zuber Single Molecule Sensing and Sequencing for Life Detection Beyond Earth Poster presented at Nanopore Community Meeting, 2016

24. Carr, CE, A Mojarro, J Tani, SAditya Bhattaru, MT Zuber, R Doebler, M Brown, K Herrington, R Talbot, CW Fuller, M Finney, G Church, G Ruvkun 2016 Advancing the search for extra-terrestrial genomes 2016 IEEE Aerospace Conference 1-15

23. Mojarro, A G Ruvkun, MT Zuber, CE Carr 2016. Methods for Extracting Nucleic Acids from Mars Analog Regolith Lunar and Planetary Science Conference, 1643

22. Mojarro, A J Hachey, J Tani, A Smith, S Bhattaru, A Pontefract, R Doebler, M Brown, G Ruvkun 2016. SETG: nucleic acid extraction and sequencing for in situ life detection on Mars 2016 3rd International Workshop on Instrumentation for Planetary Mission 1980 4095

21. Mojarro, A G Ruvkun, MT Zuber, CE Carr 2015. Human Exploration of Mars at Valles Marineris: The Past, Present, and Future of Life on Mars 2015 First Landing Site/Exploration Zone Workshop for Human Missions to the Surface of Mars 1879 1036

20. Govindan JA and G Ruvkun 2014. Pathogens. Virulence. 2014 Oct 1;5(7):695-6. doi: 10.4161/viru.36667. PMID: 25513769

19. Montgomery TA and G Ruvkun 2013. MicroRNAs visit the ER. Cell. Apr 25;153(3):511-2. doi: 10.1016/j.cell.2013.04.014. PMID: 23622236

18. Carr, CE, MT Zuber, G Ruvkun 2013 Life detection with the Enceladus Orbiting Sequencer 2013 IEEE Aerospace Conference, 1-12.

17. Carr, CE, G Ruvkun, MT Zuber 2012 In-Situ Sequencing for Life Detection, Human Health, and Planetary Protection Concepts and Approaches for Mars Exploration 1679 4210

16. Lui C, CE Carr, H Rowedder, G Ruvkun, M Zuber 2011. SETG: An instrument for detection of life on Mars ancestrally related to life on Earth. 2011 Aerospace Conference, 1-12.

15. Kabra, M AL Conery, EJ O'Rourke, X Xie, V Ljosa, TR Jones, FM Ausubel, G Ruvkun, AE Carpenter, Y Freund Towards automated high-throughput screening of C. elegans on agar. 2010 arXiv:1003.4287

14. Wu X, G Ruvkun 2010. Cancer. Germ cell genes and cancer. Science. 330:1761-2. PMID: 21205660

13. Carr, CE CS Lui, MT Zuber, G Ruvkun How the Common Ancestry Hypothesis Informs the Search for Life on Mars 2010. Astrobiology Science Conference 2010: Evolution and Life: Surviving Catastrophes and Extremes on Earth and Beyond. 1538 p5536

12. Johnson, S, Carr, C, Amils, R, Zuber, M & Ruvkun, G 2009. Extensive Sequencing Approaches to the Search for Life: Initial Results from the Rio Tinto. 40th Lunar and Planetary Science Conference, 2532.

11. Komaroff AL, Ruvkun G 2003. Unraveling the secrets of the cell. Newsweek. Dec 8; 142: 96. PMID: 14712576

10. Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T 2003. A uniform system for microRNA annotation. RNA. 9: 277-279. PMCID: PMC1370393

9. Lee SS and G Ruvkun 2002. Longevity: don't hold your breath. Nature. 418:287-8. PMID: 12124610

8. Ruvkun G 2001. Molecular Biology. Glimpses of the tiny RNA world. Science 294:797-9. PMID: 11679654

5. Slack F and G Ruvkun 1997. Temporal pattern formation by heterochronic genes. Annual Review of Genetics 31: 611-634. PMID: 9442909

4. Guarente L, Ruvkun, G, R Amasino 1998. Aging, life span, and senescence. Proc Natl Acad Sci USA 95:11034-6. PMCID: PMC33892

3. Bürglin TR, EC Lai and G Ruvkun 1993. The PBC class homeobox gene ceh-20 is expressed in the ventral nerve cord. Worm Breeder's Gazette 13: 57.

2. Ruvkun G 1992. Cell Signalling. A molecular growth industry. Nature 360: 711‑712. PMID: 1334532

1. Ruvkun G. 1976 and 1980. The Foredads, in The Coevolution Quarterly Fall 1976 and the 1980 Next Whole Earth Catalog. Sausalito, CA. Stewart Brand, ed.

The Ruvkun lab in 2025

Research Associates

Marina Kniazeva PhD

Ashwin Seetharaman PhD

Postdocs

Himani Galagali PhD

Hafiz Rothi PhD

Jenn Cohen PhD (joint with David Rudner lab at Harvard Medical School)

Ardalan Hendi PhD

Staff

Diane Sacchetti, lab administrator

Research support

Current

5 R01 GM44619-32 NIH Control of C. elegans lineage by heterochronic genes. 05/01/1991 - 01/31/25. 30% effort. Direct Costs $341,099; Total costs $573,046.

2 R01 AG016636-24 NIH Genetic and molecular basis of longevity. 20% effort. Project Period: 09/30/1999 to 05/31/2027 Direct Costs $257,119; Total costs $431,960.

Friedreich's Ataxia Accelerator. 5% effort. Supports the research on the iron sulfur cluster assembly factor gene frh-1 research. Goals: (i) identify genetic modifiers as candidate drug targets, (ii) identify new small molecules that treat worm models of disease, and (iii) identify practical oxygen-inspired therapeutic regimens using mouse models of disease. Project Number: 6000418-5500001457. PI: Mootha, Vamsi K. Broad Institute and MGH 09/01/2020 - 09/30/2026. Ruvkun lab portion: $165,528 over 3 years. Total Award 09/01/2020 to 09/30/2026: $1,356,766.

Renewal in process, A1 submission November 2024. currently no cost extension

5 R01 AG043184-25 NIH Inositol signaling in C. elegans senescence and diapause. 20% effort. 05/01/1996 - 09/30/2026. Direct Costs $276,999 Total Costs $473,668

Postdoc grant support:

Jenn Cohen, 50% Ruvkun lab, 50% Rudner lab. NRSA NIH until March 2025.

Former postdocs (58, in order of departure, 36 faculty; 15 senior scientists in industry, 4 in law, publishing, teaching, management; 23 women out of 57 postdocs, 13 women now faculty, 5 women senior scientists in industry or academia)

Om Patange University College London

Josh Meisel Assistant Professor, Brandeis University

Kai Mao Assistant Professor, Northwest Agriculture and Forestry University, Shaanxi, China

Damon Runyon Fellow

Kurt Warnhoff Assistant Professor, Sanford Research Institute, Sioux Falls, SD

Damon Runyon Fellow

Wei Wei Assistant Professor, College of Life Sciences, Capital Normal University, Beijing

Human Frontiers Fellow

Nicolas Lehrbach Assistant Professor, Division of Basic Sciences, Fred Hutchinson Cancer Research Center

Human Frontiers Fellow and Grace Foundation fellow

Maria Armakola Research Associate, Krainc lab, Northwestern University

Amaranath Govindan President, MarvelBiome

Sylvia Fischer Assistant Professor of Medicine, Harvard Medical School

EMBO Fellow, Leukemia and Lymphoma Fellow, MGH Fund for Medical Discovery

Martin Newman Research scientist, BioSkryb, Durham, North Carolina

NIH Fellow

Susana Garcia Assistant Professor, Institute of Biotechnology, Helsinki Finland

American Heart Association fellow

Rob Dowen Assistant Professor, University of North Carolina, Chapel Hill

American Cancer Society fellow

Natasha Kirienko Associate Professor, Rice University (Joint postdoc Ausubel/Ruvkun lab)

NIH Fellow

Buck Samuel Assistant Professor, Baylor College of Medicine

NIH Fellow and King Fellow

Carolyn Phillips Associate Professor, Biological Sciences, University of Southern California

Damon Runyon Fellow

Yuval Tabach Assistant Professor, Hebrew University Hadassah Hospital

Ying Liu Associate Professor, Beijing University

Helen Hay Whitney Fellow

Eyleen O’Rourke Associate Professor, Dept of Biology, University of Virginia

Human Frontiers Fellow

Taiowa Montgomery Associate Professor, Dept of Biology, Colorado State University

Damon Runyon Fellow

Yan Qi former Assistant Professor of Biology, Amherst College; now patent law in Bay Area

Life Science Research Foundation Fellow

Justine Melo former Asst Professor Biology, Haverford, Canisius College, now Univ Buffalo Law School

Jane Coffin Childs Fellow

Christian Riedel Associate Professor, Stockholm University, Stockholm

Human Frontiers Fellow

Chi Zhang Research scientist, Pfizer, NC

MGH Fund for Medical Discovery

Xiaoyun Wu Associate Principal Scientist, AstraZeneca

MGH Fund for Medical Discovery

Sean Curran Professor of Gerontology and Associate Dean, University of Southern California

NIH Fellow

Meng Wang Professor and HHMI Investigator, Baylor University School of Medicine, now Janelia Farm

Life Science Research Foundation Fellow

Alex Soukas Assistant Professor, Harvard Medical School/MGH

NIH Fellow

Andy Samuelson Assistant Professor, University of Rochester

Devin Parry Biology Teacher, The Lakeside School, Seattle

Damon Runyon Fellow

Alison Frand Associate Professor of Biochemistry, UCLA

Jane Coffin Childs Fellow

Ho Yi Mak Associate Professor, Hong Kong University of Science and Technology

Human Frontiers Fellow and MGH Fund for Medical Discovery

John Kim Associate Professor, Johns Hopkins University Department of Biology

Life Science Research Foundation Fellow

Ilya Ruvinsky former Asst Prof, Univ of Chicago Evolution; Research associate, Northwestern University

Jane Coffin Childs Fellow

Patrick Hu Associate Professor, Hematology/Oncology, Vanderbilt University

HHMI fellowship

Weiqing Li former Assistant Professor, University of Washington, now Hangzhou, China

NIH Fellow

Scott Kennedy Professor, Dept of Genetics, Harvard Medical School

NIH Fellow

Tom Isenbarger Attorney, Casimir Jones, Madison WI

Sylvia Lee Professor, Dept of Molecular Biology and Genetics, Cornell University

Damon Runyon Fellow

Kaveh Ashrafi Professor, Dept of Physiology, UCSF

Damon Runyon Fellow

Amy Pasquinelli Professor, Dept of Biology, UC San Diego

Life Science Research Foundation Fellow

Cathy Wolkow former intramural investigator, National Institutes of Aging, now nurse

Leukemia and Lymphoma Fellowship

Man Wah Tan Senior Scientist, Genentech

Harvard Junior Fellow

Raymond Lee Curator, Wormbase C. elegans database, Caltech

Sarah Pierce Senior Research Associate, King lab at University of Washington

Damon Runyon Fellow

Frank Slack Professor, Pathology, Harvard Medical School, Director, Non-coding RNA Institute

NIH Fellow

Oliver Hobert Professor of Biological Sciences and HHMI at Columbia University

Human Frontiers Fellow

Ji Ying Sze Associate Professor of Pharmacology, Albert Einstein School of Medicine

NIH Fellow

Ilho Ha Research Director, Cancer Research Center, Theragen Etex, Suwon, Korea

Scott Ogg Founding Partner DWSO Biopharma Consulting

NIH Fellow

Koutarou Kimura Professor, Nagoya City University, Japan

Garth Patterson Assistant Dean, Rutgers University

Life Science Research Foundation Fellow

Ralf Baumeister Professor, University of Freiburg, Germany

Deutsche Forschungsgemeinschaft postdoctoral fellowship

Ann Sluder Project Manager, Vaccine and Immunotherapy Center, MGH

Damon Runyon Fellow

Shoshanna Gottlieb High school teacher, Philadelphia.

Damon Runyon Fellow

David Greenstein Professor of Genetics, University of Minnesota

NIH Fellow

Tom Barnes CEO, Orna Pharmaceuticals, Cambridge

Helen Hay Whitney Fellow

Prema Arasu Professor of Veterinary Medicine, Kansas State University, Olathe

Thomas Bürglin Department of Biomedicine, University of Basel

EMBO Fellowship

Michael Finney Managing Director, Finney Capital, San Francisco

Former graduate students (14, in order of departure, 6 faculty; 4 senior scientists in industry; 8 women, 3 women now faculty, 2 women senior scientists in industry or academia; one Black man in senior management in medicine, 2 LGBTQ)

Zhen Shi Staff Scientist, Genentech

Life Science Research Foundation Fellow, in Maria Barna lab Stanford

David Shore Foley Hoag, Boston, patent attorney

Sascha Russel Founder, ScienceSuitcase, biology outreach to high schools, New York City

Harrison Gabel Assistant Professor, Department of Neuroscience, Washington University

Damon Runyon Fellow as a postdoc with Michael Greenberg at Harvard

Maurice Butler Associate Medical Director at BGB New York

Duo Wang Director Global Market Strategy, Abbott Labs, Chicago

Gisela Sandoval Clincal Associate Professor of Psychiatry, Stanford University

Gabe Hayes died October 2013

Brenda Reinhart ZS Strategy Insights & Planning Consultant Zurich

Suzanne Paradis Professor, Brandeis University

Damon Runyon Fellow as a postdoc with Michael Greenberg.

Heidi Tissenbaum Professor, University of Massachusetts at Worcester

Life Science Research Foundation Fellow as a postdoc with Lenny Guarente at MIT

Jason Morris Professor, Fordham University, New York

American Cancer Society Fellowship as a postdoc with Ruth Lehmann at NYU

Allison Koweek Schnipper Professional Organizer Services

Bruce Wightman Professor of Biology, Muhlenberg College

American Cancer Society Fellowship as a postdoc with Gian Garriga at UC Berkeley

Former Search for Extraterrestrial Genomes Team members, jointly supervised with Maria Zuber, Professor of Earth and Planetary Sciences and Vice President for Research MIT

Chris Carr Assistant Professor Georgia Institute of Technology, Aero Astro department

Angel Mojarro Graduate student in Earth and Planetary Sciences, MIT

Former undergraduates

Eric Lai Harvard, now an miRNA geneticist at Sloan Kettering NYC

Arthur Wong Harvard

Kristen Tessmar Heidelberg, now a Professor in Austria

Andy Tolonen MIT

Alexia Hwang Harvard

Ryan Klimczak Harvard, lawyer in NYC

Ellen Rim Harvard, PhD at Stanford, postdoc at UC Davis

Xinrui Zhang Harvard, medical student Case Western Reserve University.

Sandra Wellner PhD student University of Copenhagen (Jointly with Mootha)

Amanda Fuenzalida Davidson College

Elizabeth Linarte University of Massachusetts Lowell

Former high school students

Nick Ingolia MIT, Harvard PhD, UCSF postdoc (developed ribosome profiling), UC Berkeley Professor

Adrian Pearson Edinburgh University, now a marine engineer in Los Angeles

Shorter stays in the lab

Antonia De Maio Scientific editor, Cell Reports

Elamparithi Jayamani Vice-President, MarvelBiome

Nabanita De Research scientist, Beryllium Discovery

Jacob Carlson to Zack Knight lab postdoc UCSF

Life Science Research Foundation Fellow

Julie Hachey scientist, ReadCoor

Noelle Bryan Research Associate, Louisiana State University

Alexandra Pontefract Applied Physics Laboratory, John Hopkins University, research associate

Aditya Bhattaru Blue Horizons

Holli Rowedder Boston College Lab course director

Clarissa Lui Senior Hardware Engineer, Verily Life Sciences

Jacopo Tani ETH Zurich Artificial Intelligence Unit

Sarah Johnson Assistant Professor at Georgetown Univ.

Harvard Junior Fellow

Ting Zhu Assistant Professor, Tsinghua University, Beijing

Qi Pan Research scientist, Sema4

Julie Hwang Cell Biology department administration Harvard Medical School

Ravi Kamath radiologist, Arlington VA

Rob Reenan Professor of Biology, Brown University

Dan Tishkoff Research Associate, University of Michigan

Sabbatical Professor

Chris Li Professor of Biology, City College of New York

Former staff

John Giusto

Yanxia Liu, now Associate Medical Director of Imaging at Novartis Institute of Biomedical Research

Joe Gatto

Jinling Xu, now lab manager at University of Maryland

Josie Haduang, now physician

Guinevere Lourenco, now graduate student in Australia

Jonah Larkins-Ford, then PhD from Tufts Microbiology and now a scientist at MarvelBiome

Annie Conery PhD, now Enanta Pharmaceuticals

Peter Breen, now lab manager in Rob Dowen lab, UNC

Joshua Holtzman, now U Mass Amherst master’s program

Presli Green, now Northeastern University Master’s degree program

Teaching

2007 Genetics 206 (with Perrimon, Vidal). 6 lectures and discussion.

2007, 2008 Life Sciences 190, Course director, with Schrag, Kolter, Cavanaugh.

2004 to 2012 Co-director, Biology of Aging summer course, Marine Biological Laboratory, Woods Hole

2016 Four lectures Astronomy 305, Topics in Origin of Life Research

2017 Biophysics 300 lecture

2018 Biophysics 300 lecture

2019 Biophysics 300 lecture

2021 Biophysics 300: two lectures

Harvard Leadership

2003 - 2011 Harvard Microbial Sciences Initiative Organizing committee

2004 - present Harvard Origins of Life Initiative

Past advisory service

2004 - 2007 NIH National Advisory Council on Aging

2012 - 2014 Ellison Medical Foundation Scientific Advisory Board

2012 - 2017 NAS Space Studies Board, Committee on Astrobiology and Planetary Science

2015 - 2019 Chair, Genetics Section of the National Academy of Sciences

2015 - 2022 Paul Glenn Medical Foundation Scientific Advisory Board

Professional Activities

2015 - present Chair, Scientific Review Committee, Smith Family Awards Program in Biomedical Research

2018 - present California Life Sciences Company (Calico) Scientific Advisory Board

Invited Presentations 2021 to 2025

2021 McGill University (Virtual). Regulation of viral immunity in C. elegans by eri- and synMuv genes.

2021 University of Toronto, Donnelly Genome Centre (Virtual). Genetic and phylogenetic analysis of N to D protein editing of N-glycosylated proteins in C. elegans.

2021 Cold Spring Harbor Symposium on Quantitative Biology, Biological Timing (Virtual). Genetic and phylogenetic analysis of N to D protein editing of N-glycosylated proteins in C. elegans.

2021 NO Aging symposium, Oslo Norway (Virtual). Surveillance of the ribosome and mitochondria in aging and innate immunity.

2022 Sydney Brenner Festschrift at Cold Spring Harbor laboratories. Genetic and phylogenetic analysis of N to D protein editing of C. elegans and mammalian viral N-glycosylated proteins.

2022 Don Moerman Symposium at University of British Columbia. Genetic and phylogenetic analysis of N to D protein editing of C. elegans and mammalian viral N-glycosylated proteins.

2022 Vallee Symposium, Portugal. Genetic and phylogenetic analysis of N to D protein editing of C. elegans and mammalian viral N-glycosylated proteins.

2022 Brandeis University Neurobiology and Biology. Migration of Life across the Galaxy.

2022 Vertex Pharmaceuticals (Zoom). Genetic and phylogenetic analysis of N to D protein editing of C. elegans and mammalian viral N-glycosylated proteins.

2023 Society of Fellows 50th anniversary meeting, Migration of Life across the Galaxy.

2023 George Martin memorial meeting University of Washington. Activation of toxin defense of the ribosome by frameshift fusion of overlapping reading frames.

2023 Duke University Distinguished Lecture series. Activation of toxin defense of the ribosome by frameshift fusion of overlapping reading frames.

2024 Janelia Farm meeting on Whole Organismal Physiology

2024 C. elegans pathogen and RNAi meeting Madison WI. Activation of toxin defense of the ribosome by frameshift fusion of overlapping reading frames.

2024 University of California Santa Cruz. Activation of toxin defense of the ribosome by frameshift fusion of overlapping reading frames.

2024 Nobel Lecture in Physiology or Medicine. A vast and ancient hidden world of microRNAs across the eukaryotes.